Serine-protein kinase ATM

BE0004874ProteinHumansATM

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926,... It is acted on by 5 drugs in DrugBank.

Gene name
ATM
UniProtKB entry
Q13315Swiss-Prot
Cellular location
Nucleus
Residues / weight
3,056 residues · 350,684 Da
Also known as
2.7.11.1 · A-T mutated · Ataxia telangiectasia mutated

Resolves to

Protein
UniProtQ13315UniProt nameATM_HUMAN
Gene
HGNCHGNC:795NCBI Gene472GeneCardsATM
Pharmacology
IUPHAR/GtoPdb1934KEGGhsa:472
Structure
PDB5NP0PDB5NP1PDB6HKA
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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19Clinical trialsTrials of drugs acting on it, by phase and status
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26GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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102+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine-protein kinase ATM, how selective are they, and which programs against it are still in active trials?

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