Ribosomal protein S6 kinase alpha-3

BE0004876ProteinHumansRPS6KA3

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular... It is acted on by 2 drugs in DrugBank.

Gene name
RPS6KA3
UniProtKB entry
P51812Swiss-Prot
Cellular location
Nucleus
Residues / weight
740 residues · 83,735 Da
Also known as
2.7.11.1 · 90 kDa ribosomal protein S6 kinase 3 · Insulin-stimulated protein kinase 1 · ISPK-1 · ISPK1

Resolves to

Protein
UniProtP51812UniProt nameKS6A3_HUMAN
Gene
HGNCHGNC:10432NCBI Gene6197GeneCardsRPS6KA3
Pharmacology
IUPHAR/GtoPdb1528KEGGhsa:6197
Structure
PDB4D9TPDB4D9UPDB4JG6
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ribosomal protein S6 kinase alpha-3, how selective are they, and which programs against it are still in active trials?

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