Nuclear factor of activated T-cells, cytoplasmic 1

BE0004878ProteinHumansNFATC1

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. It is acted on by 2 drugs in DrugBank.

Gene name
NFATC1
UniProtKB entry
O95644Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
943 residues · 101,242 Da
Also known as
NF-ATc · NF-ATc1 · NFAT transcription complex cytosolic component · NFAT2 · NFATC

Resolves to

Protein
UniProtO95644UniProt nameNFAC1_HUMAN
Gene
HGNCHGNC:7775NCBI Gene4772GeneCardsNFATC1
Pharmacology
KEGGhsa:4772
Structure
PDB1A66PDB1NFAPDB5SVE
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nuclear factor of activated T-cells, cytoplasmic 1, how selective are they, and which programs against it are still in active trials?

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