Hyaluronan and proteoglycan link protein 1

BE0004933ProteinHumansHAPLN1

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. It is acted on by 1 drug in DrugBank.

Gene name
HAPLN1
UniProtKB entry
P10915Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
354 residues · 40,165 Da
Also known as
Cartilage-link protein · Cartilage-linking protein 1 · CRTL1 · Proteoglycan link protein

Resolves to

Protein
UniProtP10915UniProt nameHPLN1_HUMAN
Gene
HGNCHGNC:2380NCBI Gene1404GeneCardsHAPLN1
Pharmacology
KEGGhsa:1404
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hyaluronan and proteoglycan link protein 1, how selective are they, and which programs against it are still in active trials?

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