Factor VII-activating protease

BE0004940ProteinHumansHABP2

Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the... It is acted on by 1 drug in DrugBank.

Gene name
HABP2
UniProtKB entry
Q14520Swiss-Prot
Cellular location
Secreted
Residues / weight
560 residues · 62,671 Da
Also known as
3.4.21.- · FSAP · FVII activator · Hepatocyte growth factor activator-like protein · HGFAL

Resolves to

Protein
UniProtQ14520UniProt nameHABP2_HUMAN
Gene
HGNCHGNC:4798NCBI Gene3026GeneCardsHABP2
Pharmacology
KEGGhsa:3026
Drugs

What you can answer from here — as of June 26, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Factor VII-activating protease, how selective are they, and which programs against it are still in active trials?

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