Myosin light chain kinase 2, skeletal/cardiac muscle

BE0004946ProteinHumansMYLK2

Ca(2+)/calmodulin-dependent kinase that phosphorylates the regulatory light chain (RLC) of sarcomeric myosin in skeletal and cardiac muscle. It is acted on by 2 drugs in DrugBank.

Gene name
MYLK2
UniProtKB entry
Q9H1R3Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
596 residues · 64,684 Da
Also known as
2.7.11.18 · MLCK2

Resolves to

Protein
UniProtQ9H1R3UniProt nameMYLK2_HUMAN
Gene
HGNCHGNC:16243NCBI Gene85366GeneCardsMYLK2
Pharmacology
IUPHAR/GtoPdb1553KEGGhsa:85366
Structure
PDB2LV6PDB3KF9
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Myosin light chain kinase 2, skeletal/cardiac muscle, how selective are they, and which programs against it are still in active trials?

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