DNA topoisomerase 1

BE0004950ProteinStaphylococcus aureustopA

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. It is acted on by 2 drugs in DrugBank.

Gene name
topA
UniProtKB entry
Q06AK7Swiss-Prot
Residues / weight
689 residues · 79,099 Da
Also known as
5.6.2.1 · 5.99.1.2 · DNA topoisomerase I · Omega-protein · Relaxing enzyme

Resolves to

Protein
UniProtQ06AK7UniProt nameTOP1_STAAU
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
5GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
2+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on DNA topoisomerase 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In