Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds,... (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) Novobiocin sodium, a salt form of novobiocin, was initially approved in September 1964 and was indicated for the treatment of serious infections due to susceptible strains...
- Mechanism
- Curator reviewed
Novobiocin is an aminocoumarinthat works by inhibiting the GyrB subunit of the bacterial DNA gyrase enzyme involved in energy tranduction. Similar to other aminocoumarin antibiotics, it acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.
- Primary indication
- For the treatment of infections due to staphylococci and other susceptible organismsCurator reviewed
- Formula / weight
- C31H36N2O11 · 612.6243 g/mol (avg)
- Also known as
- Albamycin
- Code names
- Antibiotic PA-93
Resolves to
YJQPYGGHQPGBLI-KGSXXDOSSA-NSMILESCO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](OC2=C(C)C3=C(C=C2)C(O)=C(NC(=O)C2=CC=C(O)C(CC=C(C)C)=C2)C(=O)O3)OC1(C)CWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Novobiocin, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account