Sodium/potassium-transporting ATPase subunit beta-1

BE0004994ProteinHumansATP1B1

Non-catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It is acted on by 6 drugs in DrugBank.

Gene name
ATP1B1
UniProtKB entry
P05026Swiss-Prot
Cellular location
Cell membrane
Residues / weight
303 residues · 35,061 Da
Also known as
ATP1B · Sodium/potassium-dependent ATPase subunit beta-1

Resolves to

Protein
UniProtP05026UniProt nameAT1B1_HUMAN
Gene
HGNCHGNC:804NCBI Gene481GeneCardsATP1B1
Pharmacology
KEGGhsa:481
Structure
PDB7E1ZPDB7E20PDB7E21
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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28GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/potassium-transporting ATPase subunit beta-1, how selective are they, and which programs against it are still in active trials?

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