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Identification
- Summary
Rubidium chloride Rb-82 is a radiopharmaceutical diagnostic agent used for Positron Emission Tomography (PET) imaging of the myocardium to evaluate regional myocardial perfusion in adult patients with suspected or existing coronary artery disease.
- Brand Names
- Cardiogen-82, Ruby-fill
- Generic Name
- Rubidium Rb-82
Commonly known or available as Rubidium chloride Rb-82 - DrugBank Accession Number
- DB09479
- Background
Rubidium chloride Rb-82 injection is a sterile nonpyrogenic solutions of rubidium Rb 82 chloride. It is indicated for Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate regional myocardial perfusion in adult patients with suspected or existing coronary artery disease.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Rubidium Rb-82 (DB09479)
- Weight
- Average: 81.9177
Monoisotopic: 81.917659111 - Chemical Formula
- Rb
- Synonyms
- Rubidium (82Rb) cation
- Rubidium cation Rb-82
- Rubidium Rb-82 cation
Pharmacology
- Indication
Rubidium Rb 82 chloride injection is indicated for Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate regional myocardial perfusion in adult patients with suspected or existing coronary artery disease.
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Diagnostic agent Coronary artery disease •••••••••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
In human studies, myocardial activity was noted within the first minute after peripheral intravenous injection of Rb-82. When areas of infarction or ischemia are present in the myocardium, they are visualized within 2-7 minutes after injection as photon-deficient, or “cold”, areas on the myocardial scan. In patients with reduced cardiac function, transit of the injected dose from the peripheral infusion site to the myocardium may be delayed Blood flow brings Rb-82 to all areas of the body during the first pass of circulation. Accordingly, visible uptake is also observed in other highly vascularized organs, such as the kidneys, liver, spleen and lungs.
- Mechanism of action
Rb-82 is analogous to potassium ion (K+) in its biochemical behavior and is rapidly extracted by the myocardium proportional to the blood flow. Rb+ participates in the sodium-potassium (Na+/K+) ion exchange pumps that are present in cell membranes. The intracellular uptake of Rb-82 requires maintenance of ionic gradient across cell membranes. Rb-82 radioactivity is increased in viable myocardium reflecting intracellular retention, while the tracer is cleared rapidly from necrotic or infarcted tissue.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
Rubidium is rapidly extracted from the blood and is taken up by the myocardium in relation to myocardial perfusion, which requires energy for myocardial uptake through Na+/K+-ATPase
- Route of elimination
It is rapidly extracted by the myocardium proportional to blood flow.
- Half-life
1.27 minutes
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Rubidium chloride Rb-82 F0Z746KRKQ 132486-03-4 FGDZQCVHDSGLHJ-RYDPDVNUSA-M - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image CardioGen-82 Injection, solution 150 mCi/1 Intravenous Bracco Diagnostics Inc 1989-12-30 Not applicable US 
Ruby-fill Injection, solution 100 mCi/1 Intravenous Jubilant Draximage Inc. 2016-09-30 Not applicable US Ruby-fill Injection, solution 100 mCi/1 Intravenous Jubilant DraxImage Inc., dba Jubilant Radiopharma 2016-09-30 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- 550Z839889
- CAS number
- Not Available
- InChI Key
- NCCSSGKUIKYAJD-OIOBTWANSA-N
- InChI
- InChI=1S/Rb/q+1/i1-3
- IUPAC Name
- (82Rb)rubidium(1+) ion
- SMILES
- [82Rb+]
References
- General References
- Hasbak P, Enevoldsen LH, Fosbol MO, Skovgaard D, Knigge UP, Kjaer A: Rubidium-82 uptake in metastases from neuroendocrine tumors: No flow response to adenosine. J Nucl Cardiol. 2016 Aug;23(4):840-2. doi: 10.1007/s12350-015-0251-z. Epub 2015 Sep 10. [Article]
- LOVE WD, BURCH GE: A comparison of potassium 42, rubidium 86, and cesium 134 as tracers of potassium in the study of cation metabolism of human erythrocytes in vitro. J Lab Clin Med. 1953 Mar;41(3):351-62. [Article]
- CardioGen-82: Rubidium Rb 82 Generator [Link]
- Daily med [Link]
- External Links
- PubChem Compound
- 71357
- PubChem Substance
- 347827860
- ChemSpider
- 8351588
- 1546434
- ChEMBL
- CHEMBL1200727
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Completed Not Available Nuclear radiation emergency 2 somestatus stop reason just information to hide 3 Completed Diagnostic Coronary Artery Disease (CAD) 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, solution Intravenous 150 mCi/1 Injection, solution Intravenous 100 mCi/1 - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 0 Chemaxon pKa (Strongest Acidic) 3.09 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 0 m3·mol-1 Chemaxon Polarizability 1.78 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity)
- Specific Function
- Atp binding
- Gene Name
- ATP1A1
- Uniprot ID
- P05023
- Uniprot Name
- Sodium/potassium-transporting ATPase subunit alpha-1
- Molecular Weight
- 112895.01 Da
References
- Beck FX, Dorge A, Blumner E, Giebisch G, Thurau K: Cell rubidium uptake: a method for studying functional heterogeneity in the nephron. Kidney Int. 1988 Mar;33(3):642-51. doi: 10.1038/ki.1988.47. [Article]
- Jochumsen MR, Sorensen J, Pedersen BG, Nyengaard JR, Krag SRP, Frokiaer J, Borre M, Bouchelouche K, Tolbod LP: Tumour blood flow for prediction of human prostate cancer aggressiveness: a study with Rubidium-82 PET, MRI and Na(+)/K(+)-ATPase-density. Eur J Nucl Med Mol Imaging. 2021 Feb;48(2):532-542. doi: 10.1007/s00259-020-04998-2. Epub 2020 Aug 18. [Article]
- CardioGen-82: Rubidium Rb 82 Generator [Link]
- Daily med [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase
- Specific Function
- Atpase activator activity
- Gene Name
- FXYD2
- Uniprot ID
- P54710
- Uniprot Name
- Sodium/potassium-transporting ATPase subunit gamma
- Molecular Weight
- 7283.265 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (PubMed:19694409). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520)
- Specific Function
- Atpase activator activity
- Gene Name
- ATP1B1
- Uniprot ID
- P05026
- Uniprot Name
- Sodium/potassium-transporting ATPase subunit beta-1
- Molecular Weight
- 35061.07 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known
- Specific Function
- Atpase activator activity
- Gene Name
- ATP1B2
- Uniprot ID
- P14415
- Uniprot Name
- Sodium/potassium-transporting ATPase subunit beta-2
- Molecular Weight
- 33366.925 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known
- Specific Function
- Atpase activator activity
- Gene Name
- ATP1B3
- Uniprot ID
- P54709
- Uniprot Name
- Sodium/potassium-transporting ATPase subunit beta-3
- Molecular Weight
- 31512.34 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility
- Specific Function
- Atp binding
- Gene Name
- ATP1A4
- Uniprot ID
- Q13733
- Uniprot Name
- Sodium/potassium-transporting ATPase subunit alpha-4
- Molecular Weight
- 114165.44 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients
- Specific Function
- Atp binding
- Gene Name
- ATP1A2
- Uniprot ID
- P50993
- Uniprot Name
- Sodium/potassium-transporting ATPase subunit alpha-2
- Molecular Weight
- 112264.385 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients
- Specific Function
- Amyloid-beta binding
- Gene Name
- ATP1A3
- Uniprot ID
- P13637
- Uniprot Name
- Sodium/potassium-transporting ATPase subunit alpha-3
- Molecular Weight
- 111747.51 Da
References
Drug created at November 30, 2015 19:10 / Updated at October 07, 2021 12:09