Arsenite methyltransferase

BE0005015ProteinHumansAS3MT

Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). It is acted on by 2 drugs in DrugBank.

Gene name
AS3MT
UniProtKB entry
Q9HBK9Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
375 residues · 41,747 Da
Also known as
2.1.1.137 · CYT19 · Methylarsonite methyltransferase · S-adenosyl-L-methionine:arsenic(III) methyltransferase

Resolves to

Protein
UniProtQ9HBK9UniProt nameAS3MT_HUMAN
Gene
HGNCHGNC:17452NCBI Gene57412GeneCardsAS3MT
Pharmacology
KEGGhsa:57412
Structure
PDB8XT7
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Arsenite methyltransferase, how selective are they, and which programs against it are still in active trials?

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