Sodium/potassium-transporting ATPase subunit beta-2

BE0005018ProteinHumansATP1B2

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. It is acted on by 6 drugs in DrugBank.

Gene name
ATP1B2
UniProtKB entry
P14415Swiss-Prot
Cellular location
Cell membrane
Residues / weight
290 residues · 33,367 Da
Also known as
Adhesion molecule in glia · AMOG · Sodium/potassium-dependent ATPase subunit beta-2

Resolves to

Protein
UniProtP14415UniProt nameAT1B2_HUMAN
Gene
HGNCHGNC:805NCBI Gene482GeneCardsATP1B2
Pharmacology
KEGGhsa:482
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/potassium-transporting ATPase subunit beta-2, how selective are they, and which programs against it are still in active trials?

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