Sodium/potassium-transporting ATPase subunit beta-3

BE0005026ProteinHumansATP1B3

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. It is acted on by 6 drugs in DrugBank.

Gene name
ATP1B3
UniProtKB entry
P54709Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
279 residues · 31,512 Da
Also known as
ATPB-3 · Sodium/potassium-dependent ATPase subunit beta-3

Resolves to

Protein
UniProtP54709UniProt nameAT1B3_HUMAN
Gene
HGNCHGNC:806NCBI Gene483GeneCardsATP1B3
Pharmacology
KEGGhsa:483
Structure
PDB9KCGPDB9KCIPDB9KCJ
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/potassium-transporting ATPase subunit beta-3, how selective are they, and which programs against it are still in active trials?

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