Sodium/potassium-transporting ATPase subunit alpha-4

BE0005031ProteinHumansATP1A4

Sperm-specific catalytic alpha subunit of the Na(+)/K(+)-ATPase responsible for ATP-dependent Na(+)/K(+) exchange across the plasma membrane. It is acted on by 1 drug in DrugBank.

Gene name
ATP1A4
UniProtKB entry
Q13733Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,029 residues · 114,165 Da
Also known as
7.2.2.13 · ATP1AL2 · Na(+)/K(+) ATPase alpha-4 subunit · Sodium pump subunit alpha-4

Resolves to

Protein
UniProtQ13733UniProt nameAT1A4_HUMAN
Gene
HGNCHGNC:14073NCBI Gene480GeneCardsATP1A4
Pharmacology
KEGGhsa:480
Structure
PDB8ZYJ
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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20GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/potassium-transporting ATPase subunit alpha-4, how selective are they, and which programs against it are still in active trials?

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