Transient receptor potential cation channel subfamily V member 5

BE0005112ProteinHumansTRPV5

Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). It is acted on by 3 drugs in DrugBank.

Gene name
TRPV5
UniProtKB entry
Q9NQA5Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
729 residues · 82,561 Da
Also known as
Calcium transport protein 2 · CaT2 · ECaC · ECAC1 · Epithelial calcium channel 1

Resolves to

Protein
UniProtQ9NQA5UniProt nameTRPV5_HUMAN
Gene
HGNCHGNC:3145NCBI Gene56302GeneCardsTRPV5
Pharmacology
IUPHAR/GtoPdb511KEGGhsa:56302
Structure
PDB5OEO
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transient receptor potential cation channel subfamily V member 5, how selective are they, and which programs against it are still in active trials?

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