Transient receptor potential cation channel subfamily V member 5
Details
- Name
- Transient receptor potential cation channel subfamily V member 5
- Kind
- protein
- Synonyms
- Calcium transport protein 2
- CaT2
- ECaC
- ECAC1
- Epithelial calcium channel 1
- Osm-9-like TRP channel 3
- OTRPC3
- TrpV5
- Gene Name
- TRPV5
- UniProtKB Entry
- Q9NQA5Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0062938|Transient receptor potential cation channel subfamily V member 5 MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV LRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTA LHIAVVNQNVNLVRALLTRRASVSARATGTAFRHSPRNLIYFGEHPLSFAACVNSEEIVR LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG LTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSD KREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRT HSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTI MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTV IDAPANYDVDLPFMFSIVNFAFTIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT TVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQ EHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSE GDGEEVYHF
- Number of residues
- 729
- Molecular Weight
- 82560.88
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium channel activityProcessescalcium ion transmembrane transport / calcium ion transportComponentsapical plasma membrane / plasma membrane
- General Function
- Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity)
- Specific Function
- calcium channel activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 328-348 386-408 420-442 449-469 493-513 557-577
- Cellular Location
- Apical cell membrane
- Gene sequence
>lcl|BSEQ0020839|Transient receptor potential cation channel subfamily V member 5 (TRPV5) ATGGGGGGTTTTCTACCTAAGGCAGAAGGGCCCGGGAGCCAACTCCAGAAACTTCTGCCC TCCTTTCTGGTCAGAGAACAAGACTGGGACCAGCACCTGGACAAGCTTCATATGCTGCAG CAGAAGAGGATTCTAGAGTCTCCACTGCTTCGAGCATCCAAGGAAAATGACCTGTCTGTT CTTAGGCAACTTCTACTGGACTGCACCTGTGACGTTCGACAAAGAGGAGCCCTGGGGGAG ACGGCGCTGCACATAGCAGCCCTCTATGACAACTTGGAGGCGGCCTTGGTGCTGATGGAG GCTGCCCCAGAGCTGGTCTTTGAGCCCACCACATGTGAGGCTTTTGCAGGTCAGACTGCA CTGCACATCGCTGTTGTGAACCAGAATGTGAACCTGGTGCGTGCCCTGCTCACCCGCAGG GCCAGTGTCTCTGCCAGAGCCACAGGCACTGCCTTCCGCCATAGTCCCCGCAACCTCATC TACTTTGGGGAGCACCCTTTGTCCTTTGCTGCCTGTGTGAACAGCGAGGAGATCGTGCGG CTGCTCATTGAGCATGGAGCTGACATCAGGGCCCAGGACTCCCTGGGAAACACAGTATTA CACATCCTCATCCTCCAGCCCAACAAAACCTTTGCCTGCCAGATGTACAACCTGCTGCTG TCCTATGATGGACATGGGGACCACCTGCAGCCCCTGGACCTTGTGCCCAATCACCAGGGT CTCACCCCCTTCAAGCTGGCTGGAGTGGAGGGTAACACTGTGATGTTCCAGCACCTGATG CAGAAGCGGAGGCACATCCAGTGGACGTATGGACCCCTGACCTCCATTCTCTACGACCTC ACGGAGATCGACTCCTGGGGAGAGGAGCTGTCCTTCCTGGAGCTTGTGGTCTCCTCTGAT AAACGAGAGGCTCGCCAAATTCTGGAACAGACCCCAGTGAAGGAGCTGGTGAGCTTCAAG TGGAACAAGTATGGCCGGCCGTACTTCTGCATCCTGGCTGCCTTGTACCTGCTCTACATG ATCTGCTTTACTACGTGCTGCGTCTACCGCCCCCTTAAGTTTCGTGGTGGCAACCGCACT CATTCTCGAGACATCACCATCCTCCAGCAAAAACTACTACAGGAGGCCTATGAGACACGT GAAGATATCATCAGGCTGGTGGGGGAGCTGGTGAGCATCGTTGGGGCTGTGATCATCCTG CTCCTAGAGATTCCAGACATCTTCAGGGTTGGTGCCTCTCGCTATTTTGGAAAGACGATT CTTGGGGGGCCATTCCATGTCATCATCATCACCTATGCCTCCCTGGTGCTGGTGACCATG GTGATGCGGCTCACCAACACCAATGGGGAGGTGGTGCCCATGTCCTTTGCCCTGGTGCTG GGCTGGTGCAGTGTCATGTATTTCACTCGAGGATTCCAGATGCTGGGTCCCTTCACCATC ATGATCCAGAAGATGATTTTTGGAGACCTAATGCGTTTCTGCTGGCTGATGGCTGTGGTC ATCTTGGGATTTGCCTCCGCGTTCTATATCATTTTCCAGACAGAGGACCCAACCAGTCTG GGGCAATTCTATGACTACCCCATGGCACTGTTCACCACCTTTGAGCTTTTTCTCACTGTT ATTGATGCACCTGCCAACTACGACGTGGACTTGCCCTTCATGTTCAGCATTGTCAACTTC GCCTTCACCATCATTGCCACACTGCTCATGCTCAACTTGTTCATCGCCATGATGGGCGAC ACCCACTGGAGGGTGGCCCAGGAGAGGGATGAGCTCTGGAGGGCCCAGGTCGTGGCCACC ACAGTGATGCTGGAGCGGAAGCTGCCTCGCTGCCTGTGGCCTCGCTCCGGGATCTGTGGG TGCGAATTCGGGCTGGGGGACCGCTGGTTCCTGCGGGTTGAGAACCACAATGATCAGAAT CCTCTGCGAGTGCTTCGCTATGTGGAAGTGTTCAAGAACTCAGACAAGGAGGATGACCAG GAGCATCCATCTGAGAAACAGCCCTCTGGGGCTGAGAGTGGGACTCTAGCCAGAGCCTCT TTGGCTCTTCCAACTTCCTCCCTGTCCCGGACCGCGTCCCAGAGCAGCAGTCACCGAGGC TGGGAGATCCTTCGTCAAAACACCCTGGGGCACTTGAATCTTGGACTGAACCTTAGTGAG GGGGATGGAGAGGAGGTCTACCATTTTTGA
- Chromosome Location
- 7
- Locus
- 7q34
- External Identifiers
Resource Link UniProtKB ID Q9NQA5 UniProtKB Entry Name TRPV5_HUMAN GeneCard ID TRPV5 HGNC ID HGNC:3145 PDB ID(s) 5OEO KEGG ID hsa:56302 IUPHAR/Guide To Pharmacology ID 511 NCBI Gene ID 56302 - General References
- Muller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI, Eggert P, Garcia-Nieto V, Claverie-Martin F, Bindels RJ: Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1). Genomics. 2000 Jul 1;67(1):48-53. [Article]
- Peng JB, Brown EM, Hediger MA: Structural conservation of the genes encoding CaT1, CaT2, and related cation channels. Genomics. 2001 Aug;76(1-3):99-109. [Article]
- Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK: The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-64. [Article]
- Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC: Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-72. Epub 2003 Apr 10. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Zhang W, Na T, Peng JB: WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway. Am J Physiol Renal Physiol. 2008 Nov;295(5):F1472-84. doi: 10.1152/ajprenal.90229.2008. Epub 2008 Sep 3. [Article]
- Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Calcium citrate approved, investigational no transporter substrate Details Calcium Phosphate approved no transporter substrate Details Calcium phosphate dihydrate approved no transporter Details