Cytoplasmic aconitate hydratase

BE0005210ProteinHumansACO1

Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1281544, PubMed:1946430, PubMed:8041788). It is acted on by 1 drug in DrugBank.

Gene name
ACO1
UniProtKB entry
P21399Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
889 residues · 98,398 Da
Also known as
4.2.1.3 · Aconitase · Citrate hydro-lyase · Ferritin repressor protein · IRE-BP 1

Resolves to

Protein
UniProtP21399UniProt nameACOHC_HUMAN
Gene
HGNCHGNC:117NCBI Gene48GeneCardsACO1
Pharmacology
KEGGhsa:48
Structure
PDB2B3XPDB2B3Y
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytoplasmic aconitate hydratase, how selective are they, and which programs against it are still in active trials?

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