Neurexin-1

BE0005274ProteinHumansNRXN1

Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. It is acted on by 3 drugs in DrugBank.

Gene name
NRXN1
UniProtKB entry
Q9ULB1Swiss-Prot
Cellular location
Presynaptic cell membrane
Residues / weight
1,477 residues · 161,882 Da
Also known as
KIAA0578 · Neurexin I-alpha · Neurexin-1-alpha

Resolves to

Protein
UniProtQ9ULB1UniProt nameNRX1A_HUMAN
Gene
HGNCHGNC:8008NCBI Gene9378GeneCardsNRXN1
Pharmacology
KEGGhsa:9378
Structure
PDB6NID
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neurexin-1, how selective are they, and which programs against it are still in active trials?

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