Chloride intracellular channel protein 1

BE0005284ProteinHumansCLIC1

In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. It is acted on by 2 drugs in DrugBank.

Gene name
CLIC1
UniProtKB entry
O00299Swiss-Prot
Cellular location
Nucleus
Residues / weight
241 residues · 26,922 Da
Also known as
Chloride channel ABP · G6 · Glutaredoxin-like oxidoreductase CLIC1 · Glutathione-dependent dehydroascorbate reductase CLIC1 · hRNCC

Resolves to

Protein
UniProtO00299UniProt nameCLIC1_HUMAN
Gene
HGNCHGNC:2062NCBI Gene1192GeneCardsCLIC1
Pharmacology
KEGGhsa:1192
Structure
PDB1K0MPDB1K0NPDB1K0O
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Chloride intracellular channel protein 1, how selective are they, and which programs against it are still in active trials?

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