Ryanodine receptor 3

BE0005296ProteinHumansRYR3

Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction (PubMed:12354756, PubMed:9395096). It is acted on by 4 drugs in DrugBank.

Gene name
RYR3
UniProtKB entry
Q15413Swiss-Prot
Cellular location
Sarcoplasmic reticulum membrane
Residues / weight
4,870 residues · 552,037 Da
Also known as
Brain ryanodine receptor-calcium release channel · Brain-type ryanodine receptor · HBRR · RYR-3 · RyR3

Resolves to

Protein
UniProtQ15413UniProt nameRYR3_HUMAN
Gene
HGNCHGNC:10485NCBI Gene6263GeneCardsRYR3
Pharmacology
KEGGhsa:6263
Structure
PDB4ERVPDB6UHAPDB6UHB
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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9Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ryanodine receptor 3, how selective are they, and which programs against it are still in active trials?

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