ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

BE0005459ProteinHumansCD38

Multifunctional transmembrane glycoprotein able to exert enzymatic activities and also to mobilize calcium, to transduce signals, to adhere to hyaluronan and to other ligands. It is acted on by 10 drugs in DrugBank.

Gene name
CD38
UniProtKB entry
P28907Swiss-Prot
Cellular location
Cell surface
Residues / weight
300 residues · 34,328 Da
Also known as
2'-phospho-ADP-ribosyl cyclase · 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase · 2'-phospho-cyclic-ADP-ribose transferase · 3.2.2.- · 3.2.2.6

Resolves to

Protein
UniProtP28907UniProt nameCD38_HUMAN
Gene
HGNCHGNC:1667NCBI Gene952GeneCardsCD38
Pharmacology
IUPHAR/GtoPdb2766KEGGhsa:952
Structure
PDB1YH3PDB1ZVMPDB2EF1
Drugs

What you can answer from here — as of September 03, 2024

10DrugsApproved to experimental, with action, bond type and pharmacological action
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62Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, how selective are they, and which programs against it are still in active trials?

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