Adhesion G protein-coupled receptor D1

BE0005510ProteinHumansADGRD1

Adhesion G protein-coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed:39884271). It is acted on by 2 drugs in DrugBank.

Gene name
ADGRD1
UniProtKB entry
Q6QNK2Swiss-Prot
Cellular location
Cell membrane
Residues / weight
874 residues · 96,529 Da
Also known as
G protein-coupled receptor 133 · G protein-coupled receptor PGR25 · GPR133 · PGR25

Resolves to

Protein
UniProtQ6QNK2UniProt nameAGRD1_HUMAN
Gene
HGNCHGNC:19893NCBI Gene283383GeneCardsADGRD1
Pharmacology
KEGGhsa:283383
Structure
PDB7EPTPDB7WU2PDB8X9S
Drugs

What you can answer from here — as of June 19, 2026

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Adhesion G protein-coupled receptor D1, and which indications are they being tested in?

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