Onapristone

DB12637InvestigationalSmall molecule

Onapristone has been used in trials studying the treatment of Prostate Cancer, Recurrent Prostate Cancer, Metastatic Prostate Cancer, Androgen-independent Prostate Cancer, and Progesterone Receptor Positive Tumor: Max 1 Line of...

Mechanism: Pharmacologically active on Progesterone receptor
Curator reviewed
Formula / weight: C₂₉H₃₉NO₃ · 449.635 g/mol (avg)
Code names: ZK-98299

Resolves to

Compound

UNIIH6H7G23O3NCAS96346-61-1ChEMBLCHEMBL1908373PubChem5311505

Structure

InChIKeyIEXUMDBQLIVNHZ-YOUGDJEHSA-NSMILESCN(C)C1=CC=C(C=C1)[C@H]1C[C@]2(C)[C@@H](CC[C@]2(O)CCCO)[C@@H]2CCC3=CC(=O)CCC3=C12

Targets

P06401PGRP04150NR3C1Q6QNK2ADGRD1

What you can answer from here — as of June 15, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

39Drug interactionsStructured to mechanism, not free text

9Clinical trialsPhase, status and sponsor resolved per trial

11+ReferencesStructured and connected to the statements they support

Which drugs share a target with Onapristone, and which of those have an active Phase 3 trial?

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