Ephrin type-A receptor 5

BE0005587ProteinHumansEPHA5

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It is acted on by 2 drugs in DrugBank.

Gene name
EPHA5
UniProtKB entry
P54756Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,037 residues · 114,802 Da
Also known as
2.7.10.1 · Brain-specific kinase · BSK · EHK-1 · EHK1

Resolves to

Protein
UniProtP54756UniProt nameEPHA5_HUMAN
Gene
HGNCHGNC:3389NCBI Gene2044GeneCardsEPHA5
Pharmacology
IUPHAR/GtoPdb1825KEGGhsa:2044
Structure
PDB2R2PPDB4ET7
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ephrin type-A receptor 5, how selective are they, and which programs against it are still in active trials?

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