Mitogen-activated protein kinase kinase kinase 20

BE0005595ProteinHumansMAP3K20

Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592,... It is acted on by 3 drugs in DrugBank.

Gene name
MAP3K20
UniProtKB entry
Q9NYL2Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
800 residues · 91,154 Da
Also known as
2.7.11.25 · HCCS-4 · Human cervical cancer suppressor gene 4 protein · Leucine zipper- and sterile alpha motif-containing kinase · Mitogen-activated protein kinase kinase kinase MLT

Resolves to

Protein
UniProtQ9NYL2UniProt nameM3K20_HUMAN
Gene
HGNCHGNC:17797NCBI Gene51776GeneCardsMAP3K20
Pharmacology
IUPHAR/GtoPdb2289KEGGhsa:51776
Structure
PDB5HESPDB5X5OPDB6JUT
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase 20, how selective are they, and which programs against it are still in active trials?

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