Alpha-ketoglutarate-dependent dioxygenase FTO

BE0005795ProteinHumansFTO

RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:28002401, PubMed:30197295). It is acted on by 2 drugs in DrugBank.

Gene name
FTO
UniProtKB entry
Q9C0B1Swiss-Prot
Cellular location
Nucleus
Residues / weight
505 residues · 58,282 Da
Also known as
Fat mass and obesity-associated protein · KIAA1752 · m6A(m)-demethylase FTO · mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO · mRNA N(6)-methyladenosine demethylase FTO

Resolves to

Protein
UniProtQ9C0B1UniProt nameFTO_HUMAN
Gene
HGNCHGNC:24678NCBI Gene79068GeneCardsFTO
Pharmacology
KEGGhsa:79068
Structure
PDB3LFMPDB4CXWPDB4CXX
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-ketoglutarate-dependent dioxygenase FTO, how selective are they, and which programs against it are still in active trials?

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