G protein-coupled receptor 55

BE0005802ProteinHumansGPR55

G protein-coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:36142844, PubMed:36523570, PubMed:37544935). It is acted on by 7 drugs in DrugBank.

Gene name
GPR55
UniProtKB entry
Q9Y2T6Swiss-Prot
Cellular location
Cell membrane
Residues / weight
319 residues · 36,637 Da

Resolves to

Protein
UniProtQ9Y2T6UniProt nameGPR55_HUMAN
Gene
HGNCHGNC:4511NCBI Gene9290GeneCardsGPR55
Pharmacology
IUPHAR/GtoPdb109KEGGhsa:9290
Structure
PDB8ZX4PDB8ZX5PDB9GE2
Drugs

What you can answer from here — as of June 19, 2026

7DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on G protein-coupled receptor 55, how selective are they, and which programs against it are still in active trials?

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