Oleic monoethanolamide

DB16495InvestigationalSmall molecule

Oleic monoethanolamide: Overview.

Mechanism: Oleoylethanolamide (OEA) is a major N-acylethanolamine and an endogenous ethanolamide fatty acid. Although it is an endocannabinoids-like compound, it does not bind to cannabinoid receptors. Instead, this lipid sensor is an agonist at peroxisome proliferator-activated receptor-α (PPAR-α) agonist while also being an inhibitor of ceramidase and thereby the sphingolipid signaling pathway.
Curator reviewed
Formula / weight: C₂₀H₃₉NO₂ · 325.537 g/mol (avg)
Also known as: N-(2-Hydroxyethyl)oleamide · N-OEA · N-oleoyl ethanolamine · N-oleoylethanolamine · OEA

Resolves to

Compound

Structure

InChIKeyBOWVQLFMWHZBEF-KTKRTIGZSA-NSMILESCCCCCCCC\C=C/CCCCCCCC(=O)NCCO

Targets

What you can answer from here — as of April 21, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

15+ReferencesStructured and connected to the statements they support

Which drugs share a target with Oleic monoethanolamide, and which of those have an active Phase 3 trial?

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