TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

BE0005824ProteinHumansTAB1

Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). It is acted on by 1 drug in DrugBank.

Gene name
TAB1
UniProtKB entry
Q15750Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
504 residues · 54,644 Da
Also known as
MAP3K7IP1 · Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 · TAK1-binding protein 1 · TGF-beta-activated kinase 1-binding protein 1

Resolves to

Protein
UniProtQ15750UniProt nameTAB1_HUMAN
Gene
HGNCHGNC:18157NCBI Gene10454GeneCardsTAB1
Pharmacology
KEGGhsa:10454
Structure
PDB2J4OPDB2POMPDB2POP
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, how selective are they, and which programs against it are still in active trials?

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