Interleukin-17A

BE0005863ProteinHumansIL17A

Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:24120361). It is acted on by 12 drugs in DrugBank.

Gene name
IL17A
UniProtKB entry
Q16552Swiss-Prot
Cellular location
Secreted
Residues / weight
155 residues · 17,504 Da
Also known as
CTLA-8 · CTLA8 · Cytotoxic T-lymphocyte-associated antigen 8 · IL-17 · IL-17A

Resolves to

Protein
UniProtQ16552UniProt nameIL17_HUMAN
Gene
HGNCHGNC:5981NCBI Gene3605GeneCardsIL17A
Pharmacology
KEGGhsa:3605
Structure
PDB2VXSPDB4HR9PDB4HSA
Drugs

What you can answer from here — as of September 03, 2024

12DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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28GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-17A, how selective are they, and which programs against it are still in active trials?

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