DNA topoisomerase 4 subunit B
Details
- Name
- DNA topoisomerase 4 subunit B
- Kind
- protein
- Synonyms
- 5.99.1.3
- grlB
- Topoisomerase IV subunit B
- Gene Name
- parE
- UniProtKB Entry
- Q59192Swiss-Prot
- Organism
- Bacillus subtilis (strain 168)
- NCBI Taxonomy ID
- 224308
- Amino acid sequence
>lcl|BSEQ0037657|DNA topoisomerase 4 subunit B MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVYEIVDNSVDEVLAGHGD HIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGV GASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKIGKTKKTGTLTHFKPDPTMFS TTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVFYYENGIEAFVAYLNEEKDVLSE VVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRTKDGGTHESGAKTAMTRAFNEYARK VALLKEKDKNLEGTDIREGLSAIISVRIPEELLQFEGQTKGKLGTSEARSAVDAIVSEQL AYFLEENRDTATLLVKKAIKASQAREAARKAREEARSGKKRKKSEATLSGKLTPAGSRNP AKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIHAIG GGVGADFSIDDINYDKIIIMTDADTDGAHIQVLLLTFFYRYMKPLIEHGKVFIALPPLYK VSKGSGKKEIIEYAWSDEEMGDVLKKVGKGYTIQRYKGLGEMNADQLWETTMNPESRTLV RVKIDDAARVERRVTTLMGDKVEPRRKWIEKNVAFGLDEESNILENENLSVAEEV
- Number of residues
- 655
- Molecular Weight
- 73006.17
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / DNA binding / DNA topoisomerase type II (ATP-hydrolyzing) activity / magnesium ion bindingProcesseschromosome segregation / DNA topological change / DNA unwinding involved in DNA replicationComponentschromosome / DNA topoisomerase complex (ATP-hydrolyzing) / nucleoid
- General Function
- Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
- Specific Function
- ATP binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0015839|DNA topoisomerase 4 subunit B (parE) TTGGCTAGAAAACAGCAATTTGATTACAACGAAGATGCCATACAGGTGCTCGAAGGCCTT GAGGCTGTCAGGAAAAGGCCGGGTATGTATATTGGCTCTACTGACGCGCGGGGTTTGCAC CACTTGGTTTATGAAATTGTAGATAACTCTGTCGACGAGGTGCTTGCCGGCCATGGAGAT CACATAATCGTCAAAATACATAAAGACAATAGTATTTCTGTACAGGATAGAGGCCGCGGC ATGCCGACCGGAATGCATAAGCTCGGCAAACCAACCCCTGAAGTGATTTTAACGGTGCTT CATGCCGGAGGGAAATTCGGCCAAGGCGGCTATAAGACAAGCGGCGGGCTCCACGGAGTT GGTGCATCAGTCGTGAATGCTTTATCTGAATGGCTGACGGTTACCATTGAGCGGGACGGT TTTGTCTATCAGCAGCGATTTGAAAATGGAGGAAAACCGGTTACATCTCTCGAAAAGATC GGCAAAACAAAAAAGACGGGAACTCTTACACACTTTAAGCCAGATCCAACGATGTTCAGC ACAACCACTTATAATTTTGAAACGCTCTCTGAGCGCTTAAGAGAGTCTGCGTTTTTGTTA AAAGGACTGAAAATTGAGCTGATTGATGAACGCAATGACCAGCGTGAGGTCTTTTATTAT GAAAACGGCATAGAAGCGTTTGTTGCTTACTTAAATGAAGAAAAAGACGTCTTGTCTGAA GTGGTCTCGTTTGAGGGTGAGCATCATTCTATAGAAGTGGACTTTGCGTTCCAGTTTAAC GATGGTTATTCTGAAAATATTTTGTCGTTTGTCAACAATGTCAGAACAAAAGACGGCGGG ACGCATGAGTCAGGTGCAAAAACTGCGATGACGCGTGCTTTTAATGAATATGCGCGAAAA GTGGCTTTGCTGAAAGAAAAGGATAAGAACCTTGAAGGCACCGATATAAGGGAAGGGCTT TCAGCCATTATTTCTGTCCGCATTCCTGAGGAGCTTCTTCAATTTGAGGGACAAACAAAA GGAAAGCTCGGTACCAGTGAAGCAAGATCAGCGGTGGATGCGATTGTTTCAGAGCAGCTT GCTTACTTTTTAGAGGAAAATCGGGACACCGCAACGCTTCTTGTCAAAAAAGCAATCAAG GCGAGCCAGGCGCGCGAAGCGGCACGCAAAGCCCGTGAAGAAGCAAGAAGCGGCAAAAAA CGAAAAAAATCAGAAGCGACTTTAAGCGGAAAGCTGACGCCTGCGGGTTCAAGAAACCCG GCAAAAAATGAATTGTATCTCGTTGAGGGAGATTCAGCAGGCGGGTCAGCCAAGCAGGGA CGAGACCGCAGATTCCAGGCGGTTCTGCCTTTACGCGGTAAAGTCATTAATACAGAAAAA GCTAAGCTTGCTGATATCTTTAAAAATGAAGAGATCAATACGATCATTCATGCGATCGGC GGGGGAGTCGGGGCAGATTTCTCAATCGATGACATCAACTACGACAAAATCATCATTATG ACCGATGCCGATACTGACGGCGCCCATATTCAAGTGCTGCTTCTTACCTTTTTCTATCGC TATATGAAACCGCTCATTGAGCATGGCAAGGTGTTCATTGCGCTGCCACCTTTATATAAG GTCAGTAAAGGAAGCGGGAAAAAGGAAATCATTGAATATGCATGGTCTGATGAAGAGATG GGGGATGTCCTGAAAAAAGTCGGCAAAGGCTATACCATTCAACGATATAAGGGTCTTGGA GAGATGAACGCAGACCAGCTGTGGGAAACGACGATGAATCCGGAGTCCCGCACACTTGTT AGGGTCAAAATTGACGATGCGGCACGTGTAGAGAGACGTGTGACGACGTTAATGGGAGAC AAAGTAGAGCCGCGCAGAAAGTGGATTGAGAAAAACGTCGCTTTCGGCTTAGATGAAGAA AGCAATATTTTAGAAAATGAAAACTTATCGGTCGCTGAGGAGGTTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q59192 UniProtKB Entry Name PARE_BACSU KEGG ID bsu:BSU18090 NCBI Gene ID 936151 - General References
- Rose M, Entian KD: New genes in the 170 degrees region of the Bacillus subtilis genome encode DNA gyrase subunits, a thioredoxin, a xylanase and an amino acid transporter. Microbiology. 1996 Nov;142 ( Pt 11):3097-101. [Article]
- Huang WM, Libbey JL, van der Hoeven P, Yu SX: Bipolar localization of Bacillus subtilis topoisomerase IV, an enzyme required for chromosome segregation. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4652-7. [Article]
- Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Ciprofloxacin approved, investigational unknown target Details