Toxin B

BE0008671ProteinPeptoclostridium difficiletcdB

Toxin B Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis (PubMed:20844489, PubMed:24919149). It is acted on by 2 drugs in DrugBank.

Gene name
tcdB
UniProtKB entry
P18177Swiss-Prot
Residues / weight
2,366 residues · 269,709 Da
Also known as
3.4.22.- · tcdB · toxB

Resolves to

Protein
UniProtP18177UniProt nameTCDB_CLODI
Structure
PDB2BVLPDB2BVMPDB4NC2
Drugs

What you can answer from here — as of September 04, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Toxin B, how selective are they, and which programs against it are still in active trials?

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