Tricarboxylate transport protein, mitochondrial

BE0008676ProteinHumansSLC25A1

Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate (PubMed:26870663, PubMed:29031613, PubMed:29238895, PubMed:39881208, PubMed:38937634). It is acted on by 1 drug in DrugBank.

Gene name
SLC25A1
UniProtKB entry
P53007Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
311 residues · 34,012 Da
Also known as
CIC · Citrate transport protein · CTP · Mitochondrial citrate carrier · SLC20A3

Resolves to

Protein
UniProtP53007UniProt nameTXTP_HUMAN
Gene
HGNCHGNC:10979NCBI Gene6576GeneCardsSLC25A1
Pharmacology
IUPHAR/GtoPdb1051KEGGhsa:6576
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tricarboxylate transport protein, mitochondrial, how selective are they, and which programs against it are still in active trials?

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