Sodium citrate
Identification
- Name
- Sodium citrate
- Accession Number
- DB09154
- Description
Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works by neutralizing excess acid in the blood and urine. It has been indicated for the treatment of metabolic acidosis.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Sodium citrate (DB09154)
- Weight
- Average: 258.068
Monoisotopic: 257.97283534 - Chemical Formula
- C6H5Na3O7
- Synonyms
- Anhydrous sodium citrate
- Anhydrous trisodium citrate
- Citric acid, trisodium salt
- Natrii citras
- Natrocitral
- Sodium citrate anhydrous
- Sodium citrate, anhydrous
- Sodium citrate,anhydrous
- trisodium citrate anhydrous
- Trisodium citrate, anhydrous
- Trisodium-citrate
- External IDs
- E-331(III)
- FEMA NO. 3026, ANHYDROUS-
- INS NO.331(III)
- INS-331(III)
Pharmacology
Accelerate your drug discovery research with the industry’s only fully connected ADMET dataset, ideal for:Accelerate your drug discovery research with our fully connected ADMET dataset- Indication
Used as an anticoagulant during plasmophoresis as well as a neutralizing agent in the treatment of upset stomach and acidic urine Label 6 7.
- Associated Conditions
- Associated Therapies
- Contraindications & Blackbox Warnings
Contraindications & Blackbox WarningsWith our commercial data, access important information on dangerous risks, contraindications, and adverse effects.Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects- Pharmacodynamics
Citrate prevents activation of the clotting cascade by chelating calcium ions. Citrate neutralizes acid in the stomach and urine, raising the pH 8.
- Mechanism of action
Citrate chelates free calcium ions preventing them from forming a complex with tissue factor and coagulation factor VIIa to promote the activation of coagulation factor X 1 2. This inhibits the extrinsic initiation of the coagulation cascade. Citrate may also exert an anticoagulant effect via a so far unknown mechanism as restoration of calcium concentration does not fully reverse the effect of citrate 1. Citrate is a weak base and so reacts with hydrochloric acid in the stomach to raise the pH. It it further metabolized to bicarbonate which then acts as a systemic alkalizing agent, raising the pH of the blood and urine 8. It also acts as a diuretic and increases the urinary excretion of calcium.
- Absorption
Tmax of 98-130min 3.
- Volume of distribution
19-39L 3.
- Protein binding
- Not Available
- Metabolism
Citrate is metabolized to bicarbonate in the liver and plays a role as an intermediate in the citric acid cycle 5 9.
- Route of elimination
Largely eliminated through hepatic metabolism with very little cleared by the kidneys 3 4.
- Half-life
18-54 min 3
- Clearance
Total clearance of 313-1107mL/min 3.
- Adverse Effects
Reduce medical errorsand improve treatment outcomes with our comprehensive & structured data on drug adverse effects.Reduce medical errors & improve treatment outcomes with our adverse effects data- Toxicity
Overdose toxicity is mainly due to alkalosis as well as tetany or depressed heart function due to lack of free calcium 8.
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab The risk or severity of bleeding can be increased when Abciximab is combined with Sodium citrate. Aceclofenac The risk or severity of bleeding and hemorrhage can be increased when Aceclofenac is combined with Sodium citrate. Acemetacin The risk or severity of bleeding and hemorrhage can be increased when Acemetacin is combined with Sodium citrate. Acenocoumarol The risk or severity of bleeding can be increased when Acenocoumarol is combined with Sodium citrate. Acetophenazine Acetophenazine may increase the neurotoxic activities of Sodium citrate. Acetylsalicylic acid Acetylsalicylic acid may increase the anticoagulant activities of Sodium citrate. Albutrepenonacog alfa The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Sodium citrate. Alclofenac The risk or severity of bleeding and hemorrhage can be increased when Alclofenac is combined with Sodium citrate. Aldesleukin The risk or severity of bleeding can be increased when Sodium citrate is combined with Aldesleukin. Alemtuzumab The risk or severity of bleeding can be increased when Sodium citrate is combined with Alemtuzumab. 
Improve patient outcomesBuild effective decision support tools with the industry’s most comprehensive drug-drug interaction checker.Learn more - Food Interactions
- Take with or without food. Recommendations vary from product to product - consult individual product monographs for additional information.
Products
Comprehensive & structured drug product infoFrom application numbers to product codes, connect different identifiers through our commercial datasets.Easily connect various identifiers back to our datasets- Product Ingredients
Ingredient UNII CAS InChI Key Sodium citrate dihydrate B22547B95K 6132-04-3 NLJMYIDDQXHKNR-UHFFFAOYSA-K - Active Moieties
Name Kind UNII CAS InChI Key Citric acid unknown XF417D3PSL 77-92-9 KRKNYBCHXYNGOX-UHFFFAOYSA-N Sodium cation ionic LYR4M0NH37 17341-25-2 FKNQFGJONOIPTF-UHFFFAOYSA-N - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Anticoagulant Sod Citrate Soltn 4gm/100ml Solution 4 g Extracorporeal Baxter Laboratories 1990-12-31 Not applicable Canada 
Anticoagulant Sodium Citrate Solution 10 g/250mL Intravenous Medsep Corporation 2011-04-15 Not applicable US 
Anticoagulant Sodium Citrate 4% W/V Solution, USP Solution Unknown Haemonetics Corporation 2012-10-01 Not applicable Canada Anticoagulant Sodium Citrate Sol 4% USP Liquid Intravenous Cutter Med & Biol, Division Of Miles Canada Ltd. 1988-12-31 1996-09-09 Canada Anticoagulant Sodium Citrate Solution USP Solution 4 g Extracorporeal Fenwal, Inc. 2011-11-01 Not applicable Canada Haemonetics Anticoagulant Sodium Citrate Solution 40 mg/1mL Extracorporeal Haemonetics Corporation 2013-01-10 Not applicable US Sodium Citrate Solution 10.0 g/250mL Intravenous Haemonetics Corporation 1978-06-30 Not applicable US Sodium Citrate Blood Pack Units, (PL 146 Plastic) Solution 4 g/100mL Intravenous Fresenius Kabi USA, LLC 2014-09-29 Not applicable US Sodium Citrate Blood-Pack Units, (PL 146 Plastic) Solution 4 g/100mL Intravenous Fenwal, Inc. 2014-09-29 Not applicable US Sodium Citrate Blood-Pack Units, (PL 146 Plastic) Solution 2 g/50mL Intravenous Fenwal, Inc. 2007-03-01 Not applicable US - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Anticoagulant Sodium Citrate Solution 40 mg/1mL Extracorporeal Laboratorios Grifols Sa 2019-10-25 Not applicable US Sodium Citrate 4% w/v Anticoagulant Injection, solution 4 g/100mL Intravenous Terumo Bct, Ltd 2018-06-26 Not applicable US Sodium Citrate w/v Anticoagulant Injection, solution 4 g/100mL Intravenous Terumo Bct, Ltd 2018-06-26 Not applicable US - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Bromo Seltzer Powder 3.5 g Oral Warner Lambert Canada Inc. 1976-12-31 1999-08-13 Canada CVS Health Nausea Relief Tablet, chewable 230 mg/1 Oral CVS Pharmacy,Inc. 2019-05-22 Not applicable US Lemon Eno 2650mg/pck Powder Oral Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc. 1994-12-31 1998-08-25 Canada Nauzene Tablet, chewable 230 mg/1 Oral Alva-Amco Pharmacal Companies, Inc. 2000-07-08 Not applicable US Nauzene Grape Syrup 0.921 g/15mL Oral Alva-Amco Pharmacal Companies, Inc. 2012-04-24 2014-01-03 US Orange Eno 2645mg/pck Powder Oral Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc. 1994-12-31 1998-08-25 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image A-C-D Solution Sodium citrate (250 mg) + Citric acid (80 mg) + Dextrose, unspecified form (132 mg) Liquid Intravenous Draximage A Division Of Draxis Specialty Pharmaceuticals Inc 1959-12-31 2003-07-08 Canada Acd A Sodium citrate dihydrate (2.2 g/100mL) + Citric acid monohydrate (0.8 g/100mL) + D-glucose monohydrate (2.45 g/100mL) Injection, solution Intravenous Terumo Bct, Ltd. 2002-02-25 Not applicable US Acd A Sodium citrate (2.2 g/100mL) + Citric acid monohydrate (0.80 g/100mL) + D-glucose monohydrate (2.45 g/100mL) Injection, solution Intravenous Terumo BCT Ltd 2002-02-25 Not applicable US Acd A Sodium citrate dihydrate (2.2 g/100mL) + Citric acid monohydrate (0.8 g/100mL) + D-glucose monohydrate (2.45 g/100mL) Injection, solution Intravenous Terumo Bct, Ltd. 2002-02-25 Not applicable US ACD Blood-Pack Units (PL 146 Plastic) Sodium citrate dihydrate (1.48 g/67.5mL) + Citric acid (493 mg/67.5mL) + D-glucose monohydrate (1.65 g/67.5mL) Solution Extracorporeal Fenwal, Inc. 2007-03-01 Not applicable US Acd-A Sodium citrate (2.20 g/100mL) + Citric acid monohydrate (0.73 g/100mL) + D-glucose monohydrate (2.45 g/100mL) Solution Extracorporeal Haemonetics Corporation 1987-11-06 Not applicable US Acd-A Sodium citrate (11 g/500mL) + Citric acid (3.65 g/500mL) + D-glucose monohydrate (12.25 g/500mL) Solution Extracorporeal Fenwal, Inc. 2007-03-01 Not applicable US Acd-A Sodium citrate (2.2 g/100mL) + Citric acid (730 mg/100mL) + D-glucose monohydrate (2.45 g/100mL) Solution Extracorporeal Fenwal, Inc. 2012-10-24 Not applicable US Additive Formula 3 Sodium citrate dihydrate (0.59 g/100mL) + Adenine (0.03 g/100mL) + Citric acid monohydrate (0.042 g/100mL) + D-glucose monohydrate (1.1 g/100mL) + Sodium chloride (0.41 g/100mL) + Sodium phosphate, monobasic, monohydrate (0.28 g/100mL) Solution Intravenous Terumo Bct, Ltd 2002-05-29 Not applicable US Additive Formula 3 Sodium citrate dihydrate (0.59 g/100mL) + Adenine (0.03 g/100mL) + Citric acid monohydrate (0.042 g/100mL) + D-glucose monohydrate (1.1 g/100mL) + Sodium chloride (0.41 g/100mL) + Sodium phosphate, monobasic, monohydrate (0.28 g/100mL) Solution Intravenous Terumo Bct, Ltd 2002-05-29 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Anticoagulant Citrate Dextrose Solution-A Sodium citrate (2.20 g/100mL) + Citric acid monohydrate (0.73 g/100mL) + Dextrose, unspecified form (2.45 g/100mL) Solution Extracorporeal Biomet Biologics 2010-01-01 2010-09-06 US CVS Health Nausea Relief Sodium citrate dihydrate (230 mg/1) Tablet, chewable Oral CVS Pharmacy,Inc. 2019-05-22 Not applicable US Cytosol Ophthalmics - Balanced Salt Solution Sodium citrate dihydrate (1.70 mg/1mL) + Calcium chloride dihydrate (48 mg/1mL) + Magnesium chloride hexahydrate (30 mg/1mL) + Potassium chloride (75 mg/1mL) + Sodium acetate trihydrate (3.90 mg/1mL) + Sodium chloride (6.40 mg/1mL) Solution Irrigation Biomet Biologics 2010-01-01 2010-09-04 US Cytra 3 Sodium citrate (500 mg/5mL) + Citric acid monohydrate (334 mg/5mL) + Potassium citrate (550 mg/5mL) Syrup Oral Cypress Pharmaceuticals, Inc 2008-07-29 2014-10-11 US Cytra 3 Sodium citrate (500 mg/5mL) + Citric acid monohydrate (334 mg/5mL) + Potassium citrate (550 mg/5mL) Syrup Oral Pegasus Laboratories 2006-05-05 2009-10-17 US Cytra-2 Sodium citrate dihydrate (500 mg/5mL) + Citric acid monohydrate (334 mg/5mL) Solution Oral Cypress Pharmaceuticals, Inc. 2008-10-01 2014-10-11 US Cytra-2 Sodium citrate dihydrate (500 mg/5mL) + Citric acid monohydrate (334 mg/5mL) Liquid Oral Pegasus Laboratories 2006-05-05 2010-12-30 US EnLyte Sodium citrate (3.67 mg/1) + 1,2-docosahexanoyl-sn-glycero-3-phosphoserine calcium (6.4 mg/1) + 1,2-icosapentoyl-sn-glycero-3-phosphoserine calcium (800 ug/1) + Betaine (500 ug/1) + Citric acid monohydrate (1.83 mg/1) + Cobamamide (50 ug/1) + Cocarboxylase (25 ug/1) + Ferrous cysteine glycinate (13.6 mg/1) + Flavin adenine dinucleotide (25 ug/1) + Folic acid (1 mg/1) + Magnesium L-threonate (1 mg/1) + Leucovorin (2.5 mg/1) + Levomefolate magnesium (7 mg/1) + Magnesium ascorbate (24 mg/1) + NADH (25 ug/1) + Phosphatidyl serine (12 mg/1) + Pyridoxal phosphate (25 ug/1) + Zinc ascorbate (1 mg/1) Capsule, delayed release pellets Oral Jaymac Pharmaceuticals Llc 2011-08-12 Not applicable US Nauzene Sodium citrate dihydrate (230 mg/1) Tablet, chewable Oral Alva-Amco Pharmacal Companies, Inc. 2000-07-08 Not applicable US Nauzene Grape Sodium citrate dihydrate (0.921 g/15mL) Syrup Oral Alva-Amco Pharmacal Companies, Inc. 2012-04-24 2014-01-03 US
Categories
- ATC Codes
- B05CB02 — Sodium citrate
- Drug Categories
- Acids, Acyclic
- Antacids and Adsorbents
- Anticoagulants
- Blood and Blood Forming Organs
- Blood Substitutes and Perfusion Solutions
- Buffers
- Calculi Dissolution Agent
- Citrates
- Citric Acid Derivatives
- Compounds used in a research, industrial, or household setting
- Diet, Food, and Nutrition
- Food
- Food Additives
- Food Ingredients
- Food Preservatives
- Hematologic Agents
- Irrigating Solutions
- Laboratory Chemicals
- Miscellaneous Anticoagulants
- Miscellaneous GI Drugs
- Neurotoxic agents
- Physiological Phenomena
- Salt Solutions
- Tricarboxylic Acids
- Urinary Alkalinisers
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Tricarboxylic acids and derivatives
- Direct Parent
- Tricarboxylic acids and derivatives
- Alternative Parents
- Tertiary alcohols / Carboxylic acid salts / Carboxylic acids / Organic sodium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Alcohol / Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid salt / Hydrocarbon derivative / Organic alkali metal salt / Organic oxide / Organic oxygen compound / Organic salt
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- organic sodium salt (CHEBI:53258)
Chemical Identifiers
- UNII
- RS7A450LGA
- CAS number
- 68-04-2
- InChI Key
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K
- InChI
- InChI=1S/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
- IUPAC Name
- trisodium 2-hydroxypropane-1,2,3-tricarboxylate
- SMILES
- [Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
References
- General References
- Mann KG, Whelihan MF, Butenas S, Orfeo T: Citrate anticoagulation and the dynamics of thrombin generation. J Thromb Haemost. 2007 Oct;5(10):2055-61. [PubMed:17883701]
- Palta S, Saroa R, Palta A: Overview of the coagulation system. Indian J Anaesth. 2014 Sep;58(5):515-23. doi: 10.4103/0019-5049.144643. [PubMed:25535411]
- Kramer L, Bauer E, Joukhadar C, Strobl W, Gendo A, Madl C, Gangl A: Citrate pharmacokinetics and metabolism in cirrhotic and noncirrhotic critically ill patients. Crit Care Med. 2003 Oct;31(10):2450-5. [PubMed:14530750]
- Zheng Y, Xu Z, Zhu Q, Liu J, Qian J, You H, Gu Y, Hao C, Jiao Z, Ding F: Citrate Pharmacokinetics in Critically Ill Patients with Acute Kidney Injury. PLoS One. 2013 Jun 18;8(6):e65992. doi: 10.1371/journal.pone.0065992. Print 2013. [PubMed:23824037]
- Li K, Xu Y: Citrate metabolism in blood transfusions and its relationship due to metabolic alkalosis and respiratory acidosis. Int J Clin Exp Med. 2015 Apr 15;8(4):6578-84. eCollection 2015. [PubMed:26131288]
- FDA Monograph: Sodium Citrate Tablet [Link]
- FDA Monograph: Sodium Citrate Liquid [Link]
- TOXNET: Trisodium Citrate [Link]
- SMPDB: Citric Acid Cycle [Link]
- External Links
- KEGG Drug
- D05855
- PubChem Compound
- 6224
- PubChem Substance
- 310265067
- ChemSpider
- 5989
- 56466
- ChEBI
- 53258
- ChEMBL
- CHEMBL1355
- Wikipedia
- Sodium_citrate
- AHFS Codes
- 56:04.00 — Antacids and Adsorbents
- 20:12.04.92 — Miscellaneous Anticoagulants
- 56:92.00 — Miscellaneous GI Drugs
- FDA label
- Download (124 KB)
- MSDS
- Download (77.2 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Not Available Corneal Staining 1 4 Completed Other End Stage Renal Disease (ESRD) 1 4 Completed Treatment Arthroplasty, Knee Replacement 1 4 Completed Treatment Bacteremia 1 4 Completed Treatment Colonoscopy 1 4 Completed Treatment Heart; Dysfunction Postoperative, Cardiac Surgery 1 4 Completed Treatment Kidney Stones 1 4 Completed Treatment Obstructive Sleep Apnea (OSA) / Psoriasis 1 4 Completed Treatment Plasma Volume Replacement / Surgery of the Pancreatic Head 1 4 Recruiting Treatment Hypovolaemia 2
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Liquid Intravenous Granule, for solution Oral 370 mg Solution Irrigation; Parenteral 0.39 % Solution Intraocular Syrup Oral 5 mg/5ml Injection, solution Extracorporeal Solution Unknown Solution Extracorporeal Solution Extracorporeal 4 g Solution Extracorporeal 40 mg/1mL Solution Intravenous 10 g/250mL Solution Unknown Liquid Intravenous Solution Extracorporeal 0.8 g/100ml Solution Other 0.8 g/100ml Solution Oral 289.2 mg Solution Ophthalmic Solution Intraocular; Irrigation 1950 mg Syrup Oral 135 mg Syrup Oral 12.5 mg/5mL Granule, effervescent Oral 425 mg Injection, powder, for solution Intramuscular 25 mg Suppository Rectal 250 mg Tablet, effervescent Oral 425 mg Tablet, effervescent Oral 70 mg Solution Intravenous 0.64 g/100ml Powder, for solution Oral 289.2 mg Granule, effervescent Oral Powder, for solution Oral 52.5 g Kit Intravenous Solution Rectal 0.63 g Solution Rectal 630 mg Tablet, chewable Oral 230 mg/1 Solution Irrigation Syrup Oral Liquid Oral Solution Oral Solution Intravenous 6.4 g/L Solution Intravenous 4.21 g/1000ml Granule, for solution Oral 1.5 g Injection, solution Intravenous 5 g/L Granule, for solution Oral 650 mg Powder, for solution Oral 2.9 g Capsule, delayed release pellets Oral Solution Oral 0.294 g Syrup Oral 14 mg/5ml Syrup Oral 2 mg/mL Syrup Oral 2 mg/5mL Powder Oral 13.5 g Syrup Oral 1 mg/5mL Solution Oral 216 mg Solution Oral 0.2892 g Solution Oral 0.29 g Solution Oral 0.275 g Solution Oral 275 mg Syrup Oral 135 mg/5ml Liquid Intraocular Solution 0.64 g/100ml Solution Intravenous 0.64 % Syrup Enema Rectal 4.465 g/5ml Powder Oral Syrup Oral 125 mg/5mL Syrup Oral 62.5 mg/5mL Powder Oral 3.5 g Enema Rectal 45 mg Enema; liquid Rectal Liquid Rectal Powder, for solution Oral 658 mg Syrup Oral 0.921 g/15mL Syrup Oral 131 mg/5mL Powder, for solution Oral 0.875 g Powder, for solution Oral 0.3 g Emulsion Rectal 900 mg Syrup Oral 100 mg/5mL Solution, concentrate Oral 1.9 mg Solution Intraocular; Ophthalmic 7.8 mg Powder, for solution Oral 3.24 g Powder, for solution Oral 3.375 g Solution Oral 294 mg Solution Oral 290 mg Solution Oral 295 mg Powder Oral Solution Intravenous 0.035 % Kit Oral Syrup Oral 50 mg/5mL Tablet, chewable Oral Solution Extracorporeal 5.03 g/L Powder, for solution Oral 520 mg Enema Rectal 0.35 g Powder, for solution Oral 290 mg Powder, for solution Oral 14.1463 g Injection, solution Extracorporeal 38 MG/ML Solution Extracorporeal 38 MG/ML Solution Extracorporeal 380 MG/10ML Solution Extracorporeal 190 MG/5ML Solution Extracorporeal 76 MG/2ML Powder, for solution Oral 0.735 g Solution Intravenous 10.0 g/250mL Injection, solution Intravenous 4 g/100mL Solution Intravenous 4 g/100mL Solution Intravenous 2 g/50mL Solution Intraocular; Irrigation 0.39 g Solution Intravenous Injection, solution Intravenous Granule Oral 2.777 g Solution Extracorporeal 14 g/30mL Syrup Oral 1.325 mg/5ml Granule, for solution Oral 0.63 g Syrup Oral 333.5 mg/5ml Powder, for solution Oral 4 g Granule, effervescent Oral 720 mg Granule, effervescent Oral 720 mg/4g Liquid Ophthalmic Solution Tablet - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 300 MSDS water solubility 29.4g/L MSDS - Predicted Properties
Property Value Source Water Solubility 73.7 mg/mL ALOGPS logP -0.55 ALOGPS logP -1.3 ChemAxon logS -0.54 ALOGPS pKa (Strongest Acidic) 3.05 ChemAxon pKa (Strongest Basic) -4.2 ChemAxon Physiological Charge -3 ChemAxon Hydrogen Acceptor Count 7 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 140.62 Å2 ChemAxon Rotatable Bond Count 5 ChemAxon Refractivity 68.14 m3·mol-1 ChemAxon Polarizability 14.23 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Dicarboxylic acid transmembrane transporter activity
- Specific Function
- Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-ami...
- Gene Name
- SLC25A21
- Uniprot ID
- Q9BQT8
- Uniprot Name
- Mitochondrial 2-oxodicarboxylate carrier
- Molecular Weight
- 33302.88 Da
References
- UniProt: Mitochondrial 2-oxodicarboxylate carrier [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Low-affinity sodium:dicarboxylate symporter activity
- Specific Function
- Cotransport of sodium ions and dicarboxylates such as succinate and citrate.
- Gene Name
- SLC13A2
- Uniprot ID
- Q13183
- Uniprot Name
- Solute carrier family 13 member 2
- Molecular Weight
- 64409.495 Da
References
- UniProt: Solute carrier family 13 member 2 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Succinate transmembrane transporter activity
- Specific Function
- High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is r...
- Gene Name
- SLC13A5
- Uniprot ID
- Q86YT5
- Uniprot Name
- Solute carrier family 13 member 5
- Molecular Weight
- 63061.605 Da
References
- Inoue K, Zhuang L, Maddox DM, Smith SB, Ganapathy V: Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain. J Biol Chem. 2002 Oct 18;277(42):39469-76. Epub 2002 Aug 11. [PubMed:12177002]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Tricarboxylic acid transmembrane transporter activity
- Specific Function
- Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway.
- Gene Name
- SLC25A1
- Uniprot ID
- P53007
- Uniprot Name
- Tricarboxylate transport protein, mitochondrial
- Molecular Weight
- 34012.46 Da
References
- Sun J, Aluvila S, Kotaria R, Mayor JA, Walters DE, Kaplan RS: Mitochondrial and Plasma Membrane Citrate Transporters: Discovery of Selective Inhibitors and Application to Structure/Function Analysis. Mol Cell Pharmacol. 2010;2(3):101-110. [PubMed:20686672]
Drug created on October 01, 2015 20:41 / Updated on February 24, 2021 19:34