Na(+)/citrate cotransporter

BE0008677ProteinHumansSLC13A5

High-affinity sodium/citrate cotransporter that mediates the entry of citrate into cells, which is a critical participant of biochemical pathways (PubMed:12445824, PubMed:12826022, PubMed:26324167, PubMed:26384929, PubMed:30054523, PubMed:33597751, PubMed:39622972). It is acted on by 1 drug in DrugBank.

Gene name
SLC13A5
UniProtKB entry
Q86YT5Swiss-Prot
Cellular location
Cell membrane
Residues / weight
568 residues · 63,062 Da
Also known as
NACT · Sodium-coupled citrate transporter · Sodium-dependent citrate transporter · Solute carrier family 13 member 5

Resolves to

Protein
UniProtQ86YT5UniProt nameS13A5_HUMAN
Gene
HGNCHGNC:23089NCBI Gene284111GeneCardsSLC13A5
Pharmacology
IUPHAR/GtoPdb981KEGGhsa:284111
Structure
PDB7JSJPDB7JSKPDB8UVB
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Na(+)/citrate cotransporter, how selective are they, and which programs against it are still in active trials?

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