Mitochondrial 2-oxodicarboxylate carrier

BE0008678ProteinHumansSLC25A21

Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism (PubMed:11083877). It is acted on by 1 drug in DrugBank.

Gene name
SLC25A21
UniProtKB entry
Q9BQT8Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
299 residues · 33,303 Da
Also known as
Mitochondrial 2-oxoadipate carrier · ODC · Solute carrier family 25 member 21

Resolves to

Protein
UniProtQ9BQT8UniProt nameODC_HUMAN
Gene
HGNCHGNC:14411NCBI Gene89874GeneCardsSLC25A21
Pharmacology
KEGGhsa:89874
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitochondrial 2-oxodicarboxylate carrier, how selective are they, and which programs against it are still in active trials?

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