Flavin-dependent monooxygenase

BE0008679ProteinBacteroides thetaiotaomicrontetX2

An FAD-requiring monooxygenase active on tetracycline antibiotic derivatives, which leads to their inactivation (PubMed:15452119, PubMed:16128584). It is acted on by 1 drug in DrugBank.

Gene name
tetX2
UniProtKB entry
Q93L51TrEMBL
Residues / weight
388 residues · 43,707 Da
Also known as
TetX · TetX family tetracycline inactivation enzyme · TetX monooxygenase · TetX2 · TetX2 protein

Resolves to

Protein
UniProtQ93L51UniProt nameTETX_BACT4
Structure
PDB2XDOPDB2XYOPDB2Y6Q
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Flavin-dependent monooxygenase, and which indications are they being tested in?

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