Meclocycline is a tetracycline antibiotic indicated in the treatment of susceptible skin infections, bacterial vaginitis, vulvovaginitis, and cervicitis. Meclocycline is under investigation in clinical trial NCT00385515 (Efficacy of SNX-1012 in the Treatment of Oral Mucositis).
- Mechanism
- Curator reviewed · 1 reference
As a tetracycline, meclocycline likely works by reversably associating with the 30s subint of the bacterial ribosome. A likely binding site for tetracyclines has been identified on protein S7 of this subunit. This association blocks the association of aminoacyl-tRNA with the ribosome, inhibiting protein synthesis. Ultimately this inhibits bacterial growth due to a lack of proteins necessary for reproduction.
- Primary indication
- Currently under investigation for the topical treatment of ulcerative oral mucositisCurator reviewed · 6 structured indications
- Formula / weight
- C22H21ClN2O8 · 476.87 g/mol (avg)
- Code names
- GS-2989 · NSC-78502
Resolves to
GGQJXCQBBONZFX-IWVLMIASSA-NSMILES[H][C@@]12[C@@H](O)[C@]3([H])C(=C)C4=C(C(O)=CC=C4Cl)C(=O)C3=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)CWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Meclocycline, and which of those have an active Phase 3 trial?
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