Protein-lysine 6-oxidase

BE0008684ProteinHumansLOX

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). It is acted on by 3 drugs in DrugBank.

Gene name
LOX
UniProtKB entry
P28300Swiss-Prot
Cellular location
Secreted
Residues / weight
417 residues · 46,944 Da
Also known as
1.4.3.13 · Lysyl oxidase

Resolves to

Protein
UniProtP28300UniProt nameLYOX_HUMAN
Gene
HGNCHGNC:6664NCBI Gene4015GeneCardsLOX
Pharmacology
IUPHAR/GtoPdb3097KEGGhsa:4015
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein-lysine 6-oxidase, how selective are they, and which programs against it are still in active trials?

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