Calsequestrin-2

BE0008695ProteinHumansCASQ2

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. It is acted on by 3 drugs in DrugBank.

Gene name
CASQ2
UniProtKB entry
O14958Swiss-Prot
Cellular location
Sarcoplasmic reticulum lumen
Residues / weight
399 residues · 46,435 Da
Also known as
Calsequestrin, cardiac muscle isoform

Resolves to

Protein
UniProtO14958UniProt nameCASQ2_HUMAN
Gene
HGNCHGNC:1513NCBI Gene845GeneCardsCASQ2
Pharmacology
KEGGhsa:845
Structure
PDB2VAFPDB6OWVPDB6OWW
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calsequestrin-2, how selective are they, and which programs against it are still in active trials?

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