Calsequestrin-1

BE0008699ProteinHumansCASQ1

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:28895244). It is acted on by 4 drugs in DrugBank.

Gene name
CASQ1
UniProtKB entry
P31415Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
396 residues · 45,160 Da
Also known as
Calmitine · Calsequestrin, skeletal muscle isoform · CASQ

Resolves to

Protein
UniProtP31415UniProt nameCASQ1_HUMAN
Gene
HGNCHGNC:1512NCBI Gene844GeneCardsCASQ1
Pharmacology
KEGGhsa:844
Structure
PDB3UOMPDB5CRDPDB5CRE
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calsequestrin-1, how selective are they, and which programs against it are still in active trials?

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