Calreticulin-3
Details
- Name
- Calreticulin-3
- Kind
- protein
- Synonyms
- Calreticulin-2
- Calsperin
- CRT2
- Gene Name
- CALR3
- UniProtKB Entry
- Q96L12Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0049521|Calreticulin-3 MARALVQLWAICMLRVALATVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHK EKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQK NLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDL SYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWEQTKDNKAQDWEKHFLDASTSKQ SDWNGDLDGDWPAPMLQKPPYQDGLKPEGIHKDVWLHRKMKNTDYLTQYDLSEFENIGAI GLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEE EELLSGKINRHEHYFNQFHRRNEL
- Number of residues
- 384
- Molecular Weight
- 44995.345
- Theoretical pI
- Not Available
- GO Classification
- Functionsmetal ion binding / protein folding chaperoneProcessesERAD pathway / protein foldingComponentsendoplasmic reticulum membrane / nuclear envelope
- General Function
- During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR
- Specific Function
- carbohydrate binding
- Pfam Domain Function
- Calreticulin (PF00262)
- Signal Regions
- 1-19
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum lumen
- Gene sequence
>lcl|BSEQ0049522|Calreticulin-3 (CALR3) ATGGCCCGGGCTTTGGTCCAGCTCTGGGCCATATGCATGCTGCGAGTGGCGCTGGCTACC GTCTATTTCCAAGAGGAATTTCTAGACGGAGAGCATTGGAGAAACCGATGGTTGCAGTCC ACCAATGACTCCCGATTTGGGCATTTTAGACTTTCGTCGGGCAAGTTTTATGGTCATAAA GAGAAAGATAAAGGTCTGCAAACCACTCAGAATGGCCGATTCTATGCCATCTCTGCACGC TTCAAACCGTTCAGCAATAAAGGGAAAACTCTGGTTATTCAGTACACAGTAAAACATGAG CAGAAGATGGACTGTGGAGGGGGCTACATTAAGGTCTTTCCTGCAGACATTGACCAGAAG AACCTGAATGGAAAATCGCAGTACTATATTATGTTTGGACCCGATATTTGTGGATTTGAT ATCAAGAAAGTTCATGTTATTTTACATTTCAAGAATAAGTATCACGAAAACAAGAAACTG ATCAGGTGTAAGGTTGATGGCTTCACACACCTGTACACTCTAATTTTAAGACCAGATCTT TCTTATGATGTGAAAATTGATGGTCAGTCAATTGAATCCGGCAGCATAGAGTACGACTGG AACTTAACATCACTCAAGAAGGAAACGTCCCCGGCAGAATCGAAGGATTGGGAACAGACT AAAGACAACAAAGCCCAGGACTGGGAGAAGCATTTTCTGGACGCCAGCACCAGCAAGCAG AGCGACTGGAACGGTGACCTGGATGGGGACTGGCCAGCGCCGATGCTCCAGAAGCCCCCG TACCAGGATGGCCTGAAACCAGAAGGTATTCATAAAGACGTCTGGCTCCACCGTAAGATG AAGAATACCGACTATTTGACGCAGTATGACCTCTCAGAATTTGAGAACATTGGTGCCATT GGCCTGGAGCTTTGGCAGGTGAGATCTGGAACCATTTTTGATAACTTTCTGATCACAGAT GATGAAGAGTACGCAGATAATTTTGGCAAGGCCACCTGGGGCGAAACCAAGGGTCCAGAA AGGGAGATGGATGCCATACAGGCCAAGGAGGAAATGAAGAAGGCCCGCGAGGAAGAGGAG GAAGAGCTGCTGTCGGGAAAAATTAACAGGCACGAACATTACTTCAATCAATTTCACAGA AGGAATGAACTTTAG
- Chromosome Location
- 19
- Locus
- 19p13.11
- External Identifiers
Resource Link UniProtKB ID Q96L12 UniProtKB Entry Name CALR3_HUMAN GeneCard ID CALR3 HGNC ID HGNC:20407 KEGG ID hsa:125972 NCBI Gene ID 125972 - General References
- Nomura R, Orii M, Senda T: Calreticulin-2 is localized in the lumen of the endoplasmic reticulum but is not a Ca2+ -binding protein. Histochem Cell Biol. 2011 Jun;135(6):531-8. doi: 10.1007/s00418-011-0817-z. Epub 2011 May 18. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Persson S, Rosenquist M, Sommarin M: Identification of a novel calreticulin isoform (Crt2) in human and mouse. Gene. 2002 Sep 4;297(1-2):151-8. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Chiu C, Tebo M, Ingles J, Yeates L, Arthur JW, Lind JM, Semsarian C: Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2007 Sep;43(3):337-43. Epub 2007 Jun 30. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Calcium citrate approved, investigational unknown target ligand Details Calcium Phosphate approved unknown target ligand Details Calcium phosphate dihydrate approved unknown target Details