Polycystin-1-like protein 3

BE0008713ProteinHumansPKD1L3

Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:19464260, PubMed:23212381). It is acted on by 3 drugs in DrugBank.

Gene name
PKD1L3
UniProtKB entry
Q7Z443Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,732 residues · 195,892 Da
Also known as
PC1-like 3 protein · Polycystic kidney disease protein 1-like 3 · Polycystin-1L3

Resolves to

Protein
UniProtQ7Z443UniProt namePK1L3_HUMAN
Gene
HGNCHGNC:21716NCBI Gene342372GeneCardsPKD1L3
Pharmacology
KEGGhsa:342372
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Polycystin-1-like protein 3, how selective are they, and which programs against it are still in active trials?

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