Cation channel sperm-associated protein 1

BE0008714ProteinHumansCATSPER1

Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. It is acted on by 4 drugs in DrugBank.

Gene name
CATSPER1
UniProtKB entry
Q8NEC5Swiss-Prot
Cellular location
Cell projection, cilium, flagellum membrane
Residues / weight
780 residues · 90,090 Da
Also known as
CatSper1 · hCatSper

Resolves to

Protein
UniProtQ8NEC5UniProt nameCTSR1_HUMAN
Gene
HGNCHGNC:17116NCBI Gene117144GeneCardsCATSPER1
Pharmacology
IUPHAR/GtoPdb388KEGGhsa:117144
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cation channel sperm-associated protein 1, how selective are they, and which programs against it are still in active trials?

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