DNA-3-methyladenine glycosylase

BE0008954ProteinHumansMPG

Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. It is acted on by 6 drugs in DrugBank.

Gene name
MPG
UniProtKB entry
P29372Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
298 residues · 32,868 Da
Also known as
3-alkyladenine DNA glycosylase · 3-methyladenine DNA glycosidase · 3.2.2.21 · AAG · ADPG

Resolves to

Protein
UniProtP29372UniProt name3MG_HUMAN
Gene
HGNCHGNC:7211NCBI Gene4350GeneCardsMPG
Pharmacology
KEGGhsa:4350
Structure
PDB1BNKPDB1EWNPDB1F4R
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA-3-methyladenine glycosylase, how selective are they, and which programs against it are still in active trials?

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