Alpha-actinin-1

BE0008968ProteinHumansACTN1

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. It is acted on by 2 drugs in DrugBank.

Gene name
ACTN1
UniProtKB entry
P12814Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
892 residues · 103,057 Da
Also known as
Alpha-actinin cytoskeletal isoform · F-actin cross-linking protein · Non-muscle alpha-actinin-1

Resolves to

Protein
UniProtP12814UniProt nameACTN1_HUMAN
Gene
HGNCHGNC:163NCBI Gene87GeneCardsACTN1
Pharmacology
KEGGhsa:87
Structure
PDB2EYIPDB2EYNPDB2N8Y
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
7GO termsFunction, process and component, as structured annotations
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
25+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Alpha-actinin-1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In