Calcitonin was first discovered in isolated parathyroid tissue as a substance with a serum-calcium-lowering effect. It is constituted as a 32-amino acid single chain polypeptide structure that gets secreted as... It is used as an alternative for people developing antibodies against salmon calcitonin.
- Mechanism
- Curator reviewed · 2 references
Calcitonin inhibits osteoclast-mediated bone resorption through the regulation of the number and activity of osteoclasts. The action of human calcitonin on osteoclasts is due to a disruption of cytoskeletal organization, by the distraction of actin rings, and due to a disappearance of the cellular polarity of osteoclasts. At the subcellular level, calcitonin is suggested to perform its activity by the modulation of the cAMP-PKA signaling pathway.
- Primary indication
- Human calcitonin is indicated for the treatment of Paget's disease in the cases where the use of salmon calcitonin may provoke the generation of high-titer of antibodies.Curator reviewed
- Formula / weight
- C151H226N40O45S3 · 3417.9 Da
- Also known as
- Calcitonin (human synthetic) · Calcitonin (human) · Calcitonin human · Calcitonin, human · Calcitonin, human synthetic
- Code names
- BA-47175
Resolves to
What you can answer from here — as of June 15, 2026
Which drugs share a target with Human calcitonin, and which of those have an active Phase 3 trial?
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