Afamin

Details

Name

Afamin

Kind

protein

Synonyms

• ALB2
• ALBA
• Alpha-Alb
• Alpha-albumin

Gene Name

AFM

UniProtKB Entry

P43652Swiss-Prot

Organism

Humans

NCBI Taxonomy ID

9606

Amino acid sequence

>lcl|BSEQ0049673|Afamin
MKLLKLTGFIFFLFFLTESLTLPTQPRDIENFNSTQKFIEDNIEYITIIAFAQYVQEATF
EEMEKLVKDMVEYKDRCMADKTLPECSKLPNNVLQEKICAMEGLPQKHNFSHCCSKVDAQ
RRLCFFYNKKSDVGFLPPFPTLDPEEKCQAYESNRESLLNHFLYEVARRNPFVFAPTLLT
VAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSSYQKHVCGALLKFGTKVVHFIYI
AILSQKFPKIEFKELISLVEDVSSNYDGCCEGDVVQCIRDTSKVMNHICSKQDSISSKIK
ECCEKKIPERGQCIINSNKDDRPKDLSLREGKFTDSENVCQERDADPDTFFAKFTFEYSR
RHPDLSIPELLRIVQIYKDLLRNCCNTENPPGCYRYAEDKFNETTEKSLKMVQQECKHFQ
NLGKDGLKYHYLIRLTKIAPQLSTEELVSLGEKMVTAFTTCCTLSEEFACVDNLADLVFG
ELCGVNENRTINPAVDHCCKTNFAFRRPCFESLKADKTYVPPPFSQDLFTFHADMCQSQN
EELQRKTDRFLVNLVKLKHELTDEELQSLFTNFANVVDKCCKAESPEVCFNEESPKIGN

Number of residues

599

Molecular Weight

69068.47

Theoretical pI

Not Available

GO Classification

Processes

protein stabilization / protein transport within extracellular region

Components

cytoplasm

General Function

Functions as a carrier for hydrophobic molecules in body fluids (Probable). Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B (PubMed:26902720). Binds vitamin E (PubMed:12463752, PubMed:15952736). May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient (PubMed:15952736). May be involved in the transport of vitamin E across the blood-brain barrier (PubMed:19046407)

Specific Function

Vitamin e binding

Pfam Domain Function

• Serum_albumin (PF00273)

Signal Regions

1-21

Transmembrane Regions

Not Available

Cellular Location

Secreted

Gene sequence

>lcl|BSEQ0049674|Afamin (AFM)
ATGAAACTACTAAAACTTACAGGTTTTATTTTTTTCTTGTTTTTTTTGACTGAATCCCTA
ACCCTGCCCACACAACCTCGGGATATAGAGAACTTCAATAGTACTCAAAAATTTATAGAA
GATAATATTGAATACATCACCATCATTGCATTTGCTCAGTATGTTCAGGAAGCAACCTTT
GAAGAAATGGAAAAGCTGGTGAAAGACATGGTAGAATACAAAGACAGATGTATGGCTGAC
AAGACGCTCCCAGAGTGTTCAAAATTACCTAATAATGTTTTACAGGAAAAAATATGTGCT
ATGGAGGGGCTGCCACAAAAGCATAATTTCTCACACTGCTGCAGTAAGGTTGATGCTCAA
AGAAGACTCTGTTTCTTCTATAACAAGAAATCTGATGTGGGATTTCTGCCTCCTTTCCCT
ACCCTGGATCCCGAAGAGAAATGCCAGGCTTATGAAAGTAACAGAGAATCCCTTTTAAAT
CACTTTTTATATGAAGTTGCCAGAAGGAACCCATTTGTCTTCGCCCCTACACTTCTAACT
GTTGCTGTTCATTTTGAGGAGGTGGCCAAATCATGTTGTGAAGAACAAAACAAAGTCAAC
TGCCTTCAAACAAGGGCAATACCTGTCACACAATATTTAAAAGCATTTTCTTCTTATCAA
AAACATGTCTGTGGGGCACTTTTGAAATTTGGAACCAAAGTTGTACACTTTATATATATT
GCGATACTCAGTCAAAAATTCCCCAAGATTGAATTTAAGGAGCTTATTTCTCTTGTAGAA
GATGTTTCTTCCAACTATGATGGATGCTGTGAAGGGGATGTTGTGCAGTGCATCCGTGAC
ACGAGCAAGGTTATGAACCATATTTGTTCAAAACAAGATTCTATCTCCAGCAAAATCAAA
GAGTGCTGTGAAAAGAAAATACCAGAGCGCGGCCAGTGCATAATTAACTCAAACAAAGAT
GATAGACCAAAGGATTTATCTCTAAGAGAAGGAAAATTTACTGACAGTGAAAATGTGTGT
CAAGAACGAGATGCTGACCCAGACACCTTCTTTGCGAAGTTTACTTTTGAATACTCAAGG
AGACATCCAGACCTGTCTATACCAGAGCTTTTAAGAATTGTTCAAATATACAAAGATCTC
CTGAGAAATTGCTGCAACACAGAAAACCCTCCAGGTTGTTACCGTTACGCGGAAGACAAA
TTCAATGAGACAACTGAGAAAAGCCTCAAGATGGTACAACAAGAATGTAAACATTTCCAG
AATTTGGGGAAGGATGGTTTGAAATACCATTACCTCATCAGGCTCACGAAGATAGCTCCC
CAACTCTCCACTGAAGAACTGGTGTCTCTTGGCGAGAAAATGGTGACAGCTTTCACTACT
TGCTGTACGCTAAGTGAAGAGTTTGCCTGTGTTGATAATTTGGCAGATTTAGTTTTTGGA
GAGTTATGTGGAGTAAATGAAAATCGAACTATCAACCCTGCTGTGGACCACTGCTGTAAA
ACAAACTTTGCCTTCAGAAGGCCCTGCTTTGAGAGTTTGAAAGCTGATAAAACATATGTG
CCTCCACCTTTCTCTCAAGATTTATTTACCTTTCACGCAGACATGTGTCAATCTCAGAAT
GAGGAGCTTCAGAGGAAGACAGACAGGTTTCTTGTCAACTTAGTGAAGCTGAAGCATGAA
CTCACAGATGAAGAGCTGCAGTCTTTGTTTACAAATTTCGCAAATGTAGTGGATAAGTGC
TGCAAAGCAGAGAGTCCTGAAGTCTGCTTTAATGAAGAGAGTCCAAAAATTGGCAACTGA

Chromosome Location

4

Locus

4q13.3

External Identifiers

Resource	Link
UniProtKB ID	P43652
UniProtKB Entry Name	AFAM_HUMAN
GeneCard ID	AFM
HGNC ID	HGNC:316
PDB ID(s)	5OKL, 6FAK, 6RQ7
KEGG ID	hsa:173
NCBI Gene ID	173

General References

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Associated Data

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
Copper	approved, investigational	unknown	target		Details