Protein disulfide-isomerase A3

BE0008980ProteinHumansPDIA3

Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). It is acted on by 5 drugs in DrugBank.

Gene name
PDIA3
UniProtKB entry
P30101Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
505 residues · 56,782 Da
Also known as
5.3.4.1 · 58 kDa glucose-regulated protein · 58 kDa microsomal protein · Disulfide isomerase ER-60 · Endoplasmic reticulum resident protein 57

Resolves to

Protein
UniProtP30101UniProt namePDIA3_HUMAN
Gene
HGNCHGNC:4606NCBI Gene2923GeneCardsPDIA3
Pharmacology
IUPHAR/GtoPdb3293KEGGhsa:2923
Structure
PDB2ALBPDB2DMMPDB2H8L
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein disulfide-isomerase A3, how selective are they, and which programs against it are still in active trials?

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