Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

BE0008997ProteinHumansCMTR1

S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. It is acted on by 1 drug in DrugBank.

Gene name
CMTR1
UniProtKB entry
Q8N1G2Swiss-Prot
Cellular location
Nucleus
Residues / weight
835 residues · 95,320 Da
Also known as
2.1.1.57 · Cap methyltransferase 1 · Cap1 2'O-ribose methyltransferase 1 · FtsJ methyltransferase domain-containing protein 2 · FTSJD2

Resolves to

Protein
UniProtQ8N1G2UniProt nameCMTR1_HUMAN
Gene
HGNCHGNC:21077NCBI Gene23070GeneCardsCMTR1
Pharmacology
KEGGhsa:23070
Structure
PDB4N48PDB4N49PDB4N4A
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, how selective are they, and which programs against it are still in active trials?

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