Macrophage receptor MARCO

Details

Name
Macrophage receptor MARCO
Kind
protein
Synonyms
  • Macrophage receptor with collagenous structure
  • SCARA2
  • Scavenger receptor class A member 2
Gene Name
MARCO
UniProtKB Entry
Q9UEW3Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0049716|Macrophage receptor MARCO
MRNKKILKEDELLSETQQAAFHQIAMEPFEINVPKPKRRNGVNFSLAVVVIYLILLTAGA
GLLVVQVLNLQARLRVLEMYFLNDTLAAEDSPSFSLLQSAHPGEHLAQGASRLQVLQAQL
TWVRVSHEHLLQRVDNFTQNPGMFRIKGEQGAPGLQGHKGAMGMPGAPGPPGPPAEKGAK
GAMGRDGATGPSGPQGPPGVKGEAGLQGPQGAPGKQGATGTPGPQGEKGSKGDGGLIGPK
GETGTKGEKGDLGLPGSKGDRGMKGDAGVMGPPGAQGSKGDFGRPGPPGLAGFPGAKGDQ
GQPGLQGVPGPPGAVGHPGAKGEPGSAGSPGRAGLPGSPGSPGATGLKGSKGDTGLQGQQ
GRKGESGVPGPAGVKGEQGSPGLAGPKGAPGQAGQKGDQGVKGSSGEQGVKGEKGERGEN
SVSVRIVGSSNRGRAEVYYSGTWGTICDDEWQNSDAIVFCRMLGYSKGRALYKVGAGTGQ
IWLDNVQCRGTESTLWSCTKNSWGHHDCSHEEDAGVECSV
Number of residues
520
Molecular Weight
52657.905
Theoretical pI
Not Available
GO Classification
Functions
amyloid-beta binding / cargo receptor activity / G protein-coupled receptor binding / pattern recognition receptor activity
Processes
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / amyloid-beta clearance / phagocytosis, engulfment / positive regulation of ERK1 and ERK2 cascade / positive regulation of protein phosphorylation
Components
collagen-containing extracellular matrix / cytoplasm
General Function
Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263)
Specific Function
Amyloid-beta binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
44-64
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0049717|Macrophage receptor MARCO (MARCO)
ATGAGAAATAAGAAAATTCTCAAGGAGGACGAGCTCTTGAGTGAGACCCAACAAGCTGCT
TTTCACCAAATTGCAATGGAGCCTTTCGAAATCAATGTTCCAAAGCCCAAGAGGAGAAAT
GGGGTGAACTTCTCCCTAGCTGTGGTGGTCATCTACCTGATCCTGCTCACCGCTGGCGCT
GGGCTGCTGGTGGTCCAAGTTCTGAATCTGCAGGCGCGGCTCCGGGTCCTGGAGATGTAT
TTCCTCAATGACACTCTGGCGGCTGAGGACAGCCCGTCCTTCTCCTTGCTGCAGTCAGCA
CACCCTGGAGAACACCTGGCTCAGGGTGCATCGAGGCTGCAAGTCCTGCAGGCCCAACTC
ACCTGGGTCCGCGTCAGCCATGAGCACTTGCTGCAGCGGGTAGACAACTTCACTCAGAAC
CCAGGGATGTTCAGAATCAAAGGTGAACAAGGCGCCCCAGGTCTTCAAGGTCACAAGGGG
GCCATGGGCATGCCTGGTGCCCCTGGCCCGCCGGGACCACCTGCTGAGAAGGGAGCCAAG
GGGGCTATGGGACGAGATGGAGCAACAGGCCCCTCGGGACCCCAAGGCCCACCGGGAGTC
AAGGGAGAGGCGGGCCTCCAAGGACCCCAGGGTGCTCCAGGGAAGCAAGGAGCCACTGGC
ACCCCAGGACCCCAAGGAGAGAAGGGCAGCAAAGGCGATGGGGGTCTCATTGGCCCAAAA
GGGGAAACTGGAACTAAGGGAGAGAAAGGAGACCTGGGTCTCCCAGGAAGCAAAGGGGAC
AGGGGCATGAAAGGAGATGCAGGGGTCATGGGGCCTCCTGGAGCCCAGGGGAGTAAAGGT
GACTTCGGGAGGCCAGGCCCACCAGGTTTGGCTGGTTTTCCTGGAGCTAAAGGAGATCAA
GGACAACCTGGACTGCAGGGTGTTCCGGGCCCTCCTGGTGCAGTGGGACACCCAGGTGCC
AAGGGTGAGCCTGGCAGTGCTGGCTCCCCTGGGCGAGCAGGACTTCCAGGGAGCCCCGGG
AGTCCAGGAGCCACAGGCCTGAAAGGAAGCAAAGGGGACACAGGACTTCAAGGACAGCAA
GGAAGAAAAGGAGAATCAGGAGTTCCAGGCCCTGCAGGTGTGAAGGGAGAACAGGGGAGC
CCAGGGCTGGCAGGTCCCAAGGGAGCCCCTGGACAAGCTGGCCAGAAGGGAGACCAGGGA
GTGAAAGGATCTTCTGGGGAGCAAGGAGTAAAGGGAGAAAAAGGTGAAAGAGGTGAAAAC
TCAGTGTCCGTCAGGATTGTCGGCAGTAGTAACCGAGGCCGGGCTGAAGTTTACTACAGT
GGTACCTGGGGGACAATTTGCGATGACGAGTGGCAAAATTCTGATGCCATTGTCTTCTGC
CGCATGCTGGGTTACTCCAAAGGAAGGGCCCTGTACAAAGTGGGAGCTGGCACTGGGCAG
ATCTGGCTGGATAATGTTCAGTGTCGGGGCACGGAGAGTACCCTGTGGAGCTGCACCAAG
AATAGCTGGGGCCATCATGACTGCAGCCACGAGGAGGACGCAGGCGTGGAGTGCAGCGTC
TGA
Chromosome Location
2
Locus
2q14.2
External Identifiers
ResourceLink
UniProtKB IDQ9UEW3
UniProtKB Entry NameMARCO_HUMAN
GeneCard IDMARCO
HGNC IDHGNC:6895
KEGG IDhsa:8685
NCBI Gene ID8685
General References
  1. Elomaa O, Sankala M, Pikkarainen T, Bergmann U, Tuuttila A, Raatikainen-Ahokas A, Sariola H, Tryggvason K: Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region. J Biol Chem. 1998 Feb 20;273(8):4530-8. [Article]
  2. Kangas M, Brannstrom A, Elomaa O, Matsuda Y, Eddy R, Shows TB, Tryggvason K: Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor. Genomics. 1999 May 15;58(1):82-9. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Silicon dioxideapprovedunknowntargetDetails
Titanium dioxideapprovedunknowntargetDetails